Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis.
نویسندگان
چکیده
منابع مشابه
Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis
Surface IgM (sIgM) stimulation induces the tyrosine phosphorylation of multiple cellular substrates, including phospholipase C (PLC)-gamma 2, which is involved in the activation of phosphatidylinositol pathway. DT40 B cells underwent apoptotic cell death when activated through sIgM, a phenomenon that is related to elimination of self-reactive B cells. To examine the roles of PLC-gamma 2 in sIgM...
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Surface IgM (slgM) stimulation induces the tyrosine phosphorylation of multiple cellular substrates, including phospholipase C (PLC)-'~/2, which is involved in the activation ofphosphatidyhnositol pathway. DT40 B cells underwent apoptotic cell death when activated through slgM, a phenomenon that is related to elimination of self-reactive B cells. To examine the roles of PLC-~/2 in slgM signalin...
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The role of cell surface immunoglobulin in helper T-cell-dependent B-cell activation was analyzed using a B-cell lymphoma, CH12, with known antigen specificity and activation properties similar to those of a resting B cell. Two sources of helper T cells were used, both selected such that they interact with H-2-encoded determinants on CH12 in the absence of the specific B-cell antigen, sheep ery...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1995
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.182.4.907